Managing modularity and ensuring maintainability in Python applications can be challenging as projects grow. Clean Architecture addresses these issues by promoting separation of concerns and system independence. In this talk, we’ll explore Clean Architecture’s layered approach, starting with domain models to enforce business rules. We’ll then integrate these models with use cases and repositories, showcasing effective layering and dependency management. Interface adapters and their role in connecting external requests to internal logic will also be discussed. The session concludes by demonstrating how to package these components for delivery, focusing on modularity and testability. Attendees will gain practical insights for applying Clean Architecture in Python to create scalable and maintainable applications.